The incidenceof ER, PR and HER2/neuin breast cancer cases in ruralThiruporur, Kancheepuram district - Tamilnadu

Aim: Receptor status study in breast cancer is uncommon in rural population in India. Our aim in this study is to evaluate the expression of hormone receptors Estrogen receptor (ER), Progesterone receptor (PR) along with Human Epidermal growth receptor 2 (HER2/neu) expression in breast cancer cells and distribution with regards to age, menopausal status, tumor size, histological grading and lymph node status. Materials and Method: This is a six-year retrospective study from 2011-2016. The sample consisted of 27 patients(26-female and 1-male) who underwent treatment in the town of Thiruporur, Kancheepuram district, Tamilnadu. In routine H&E sections diagnosed as breast cancer IHC was used to evaluate the expression of ER, PR and HER2/neu. Results:The proportion of each type in our patient population was ER/PR 15 cases (56%) and HER2/neu was 7 cases (26%). 8 cases (30%) were negative for all the 3 receptors and distribution with regards to age, menopausal status, tumor size, histological grading and lymph node status was also studied. Conclusions:Hormone receptors were inversely related to HER2/neu. ER and PR were directly related. Breast cancer patients should be subjected to immunohistochemistry to find out the status of hormone receptors for recommending hormone therapy and Herceptin for overexpression of HER2/neu.